How Does Curcumin Modulate the Immune System at the Cellular Level?
One molecule hits NF-κB, MAPK, and JAK/STAT simultaneously — decreasing regulatory T cells while driving Th1 effector output higher. Suppression and activation, from the same compound. Curcumin, the primary polyphenolic compound in turmeric (Curcuma longa), modulates immune cell behavior by directly interfering with at least four intracellular signaling cascades — NF-κB, MAPKs, JAK/STAT, and Notch-1. … Read more